Title: Nanostructures-enabled microchips for detecting chemicals released from neural cells under external stimulation.
Abstract: The emerging technology of brain-on-a-chip devices holds great promise for advancing our understanding of physiological and pathological events within the brain. By replicating the microenvironment of the brain on a microfluidic chip, this approach enables the study of disease mechanisms and the evaluation of external interventions such as chemical excitation and shockwave stimulation. This technology has been recognized as one of the top 10 emerging technologies due to its potential impact on drug development, reduced reliance on 
animal testing, and improved understanding of cell function and communication.
In this study, a modified microfluidic chip with an integrated cell-culture chamber was developed to directly detect dopamine released from N27-A dopaminergic neural cells, a widely used model for Parkinson’s disease research. Additionally, a microchip was designed to assess the effects of shockwave impacts on adult rat hippocampal progenitor cell (AHPC) Neurospheres (NSs), serving as in vitro models for traumatic brain injury (TBI) research.
These developments hold significant implications for both basic research and drug development in neurological disorders. The ability to directly detect dopamine release from neural cells offers insights into Parkinson’s disease pathology, while assessing shockwave impacts on AHPC NSs provides valuable information about TBI mechanisms. Overall, these advancements in brain-on-a-chip technology have the potential to revolutionize our approach to studying and treating neurological conditions while reducing reliance on traditional animal-based testing methods.
Bio: Md Fazlay Rubby is a dedicated Ph.D. candidate in Electrical and Computer Engineering at Iowa State University. He has garnered a robust foundation in microfabrication and semiconductor processes, complemented by hands-on experience and a commitment to advancing technology in the field. Rubby’s academic journey began with a B.Sc. in Mechanical Engineering from the Bangladesh University of Engineering and Technology, followed by a master’s degree in electrical and computer engineering from the University of Texas Rio Grande Valley. This strong educational background laid the groundwork for his research interests and technical skills. Throughout his academic career, Rubby has amassed over four years of hands-on experience in microfabrication techniques, including lithography, thin film deposition, and etching. His research has concentrated on developing microfabrication-compatible methods for creating silicon nanostructures, particularly for applications in nanoprobe technology.
With a passion for advancing research and technology, Md Fazlay Rubby continues to push the boundaries of his field, combining his extensive knowledge of microfabrication and sensor development with a desire to make impactful contributions to the engineering community.
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